usual suspect wrote in message
news:oYmRe.203471$0f.47354@tornado.texas.rr.com...
> pearl cut-and-pasted:
> >>>The Independent
> >>>August 29, 2005
> >>>THE GREEN GODDESS: A VICTORY FOR GOOD SENSE
> >>>AND GUINEA PIGS
> >>>
> >>>JULIA STEPHENSON
> >>>
> >>>I cheered when I heard that Darley Oaks guinea pig farm is to close.
> >>
> >>I didnt. Its a set back for medical progress. But then again, when did
> >>ARAs ever care about human welfare, much less human progress? Animal
> >>rights activists are misanthropes.
> >
> >
> > According to the United States Food and Drug Administration,
> > 1.5 million Americans were hospitalised in 1978 alone,
>
> You have anything from THIS century, much less this decade, dummy?
Even from this millennium, misanthrope.
Painkiller caused 139,000 heart attacks
August 29, 2005
Many policymakers believe an independent drug safety office
should be created to review the safety of medications
By DAGI KIMANI
Special Correspondent
According to the Financial Times, Vioxx has had a troubled
history dating back to September last year, when the manufacturer
announced it had withdrawn the drug after clinical tests linked it with
increased risk of heart attacks and other cardiovascular problems.
The recall, said the papers August 24 issue, came more than
three years after researchers in another study attributed incidents
of heart attacks and strokes to the drug.
But suspicions about the side-effects of the drug first arose in
June 2001, when the Journal of the American Medical Association
(JAMA) released a report showing that it could cause kidney
problems. A subsequent report in the jounal, said the FT, reported
incidents of serious heart problems in Vioxx users, including heart
attacks.
The day after Merck announced the Vioxx recall, a Federal Drug
Agency official was reported as saying the agency had been aware
of the potential for serious heart problems for years. In fact, said
the FT, in 2000 the agency required Merck to place a warning
label on the drug warning users of the potential for heart problems.
In spite of the strong warnings presented in multiple studies,
Merck is said to have continued marketing the drug. After Merck,
in a shock announcement in November 2004, stated that the drug
should not have been pulled earlier, many people in the medical
community criticised the manufacturer for responding slowly to
evidence of health risks and serious side effects.
FT reported that Merck & Co had conducted a clinical study
involving 2,600 patients to determine whether the drug was
effective in preventing colon cancer. But it halted the study
before its conclusion after it became clear that it increased the
risk of heart attacks and other serious cardiovascular problems.
In August last year, just a month prior to the withdrawal, the firm,
according to the FT report, released a press statement contending
that the drug was safe. The company said it stood behind the
overall safety and cardiovascular safety of Vioxx. It dismissed
studies from other research groups that found a link between the
drug and heart attacks, strokes, blood clots, and other serious
side effects.
It was estimated that more than 84 million people had taken the
drug worldwide and it is believed more than two million were
taking it to cure arthritis at the time of the recall.
It is believed that the widespread use was the result of an
aggressive marketing campaign by the drug company. Merck
reportedly spent about $100 million per year promoting the
drug, with most of it being spent after researchers had already
had reported a link between Vioxx and heart problems.
According to the FT report, the FDA has estimated that
Vioxx may be responsible for as many as 27,000 heart attacks
and cardiac deaths between 1999 and 2003. The Agency is
said to have reached this number by analysing a database of
1.4 million patients in the Kaiser Permanente health care system
in the US. That analysis also led to the finding that Vioxx users
were more likely to suffer a heart attack or sudden cardiac death
than those who took a competing drug, said the newspaper.
Intriguingly, said the FT, the problems with Vioxx began before
the drug was approved for sale in the US.
Pre-approval trials to determine the safety of the drug lasted less
than 12 months, in spite of the fact that many people taking Vioxx
for arthritis would use the drug for a much longer period of time.
Last November, Congress began hearings intended to assess the
Agencys decision not to recall Vioxx years before the drug finally
was pulled from the market. Dr. Graham, the Associate Director
for Science in the Agencys Office of Drug Safety testified that
the agency is incapable of protecting America against another
Vioxx, said the FT.
He estimated that the drug had caused between 88,000 and
139,000 cases of heart attack and stroke. These numbers are
significantly greater than the 27,000 estimate announced by the
Agency a month earlier.
During the hearing, one senator expressed concern that the
FDA was too cozy with drug companies. Many policymakers
believe an independent drug safety office should be created to
review the safety of medications following FDA approval, said
the report.
.
http://www.nationmedia.com/eastafrican/current/News/Regional290820052.htm
Source: BioMed Central
Date: 2005-08-22
Antidepressant Paroxetine Linked To Higher Rate Of Suicide
Attempts In Adults
Adult patients taking the antidepressant drug paroxetine are at
higher risk of attempting to commit suicide than those not taking
medication. A new analysis, published in BMC Medicine, of
previous clinical data on paroxetine use adds the antidepressant
to the list of Selective Serotonin Reuptake Inhibitors (SSRIs)
that have been shown to increase suicidal tendencies in adult
patients with depression.
....
http://www.sciencedaily.com/releases/2005/08/050821225354.htm
Source: Journal Of The American Medical Association
Date: 2004-11-26
Antidepressants May Increase Risk Of Abnormal Bleeding
CHICAGO -- New users of selective serotonin reuptake
inhibitors (SSRIs, a type of antidepressant) have an increased
risk of being admitted to the hospital for abnormal bleeding,
according to an article in the November 22 issue of the Archives
of Internal Medicine, one of the JAMA/Archives journals.
...
http://www.sciencedaily.com/releases/2004/11/041123113444.htm
Drugging Kids with Lethal Medications
On June 18, 2003, GlaxoSmithKline issued a warning to
British physicians against the use of Paxil in children, and
acknowledged its failure in clinical trials to demonstrate
efficacy in major depressive disorders and doubling the
rate of reported adverse events-including suicidal
thoughts and suicide attempts-compared to placebo.
.....
http://onlinejournal.com/health/082605Pringle/082605pringle.html
............